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Weight Maintenance Synergy: The benefits of combining medication therapy with increased physical activity mirror evidence from exercise-plus-liraglutide studies, highlighting that lifestyle interventions coupled with GLP-1 receptor agonists can enhance weight reduction and metabolic control

These results show that GLP-1RA can induce phosphorylated AMPK expression (91), inhibit the expression and phosphorylation of the mTOR protein (92), promote the apoptosis of endometrial cancer cells, and thus play a potential anticancer role

Some prescription therapies (including tirzepatide) are dual-acting, meaning they work on two hormone pathwaysGLP-1 and GIPinstead of GLP-1 alone